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NIH Invitation to Submit Research Protocols
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There are several related FOAs from NICHD revolving around the adolescent reproductive transition that may be of interest to NASPAG members.

A cross cutting theme from the GHDB Scientific Vision Meeting was the need to stimulate study of the adolescent period in relation to the development of gynecologic conditions. In response to this recommendation, GHDB worked the Fertility and Infertility branch to craft the following FOAs.

Of particular note, while the FOAs do encompass normal pubertal development, the research scope also includes:


  • Investigation of menstrual cycle characteristics such as bleeding, pain, menstrual irregularity during the peripubertal transition in relationship to development of future reproductive and gynecologic diseases and disorders to establish normal ranges across the age spectrum and across populations.
  • Accurate and precise characterization of normal and abnormal anatomic, morphologic and biochemical characteristics across adolescence with regard to age, ethnicity and race.

These FOAs welcome a wide range of projects than can apply to GHDB conditions of interest, including fibroids, endometriosis, adenomyosis, pelvic pain, and pelvic floor disorders. Understanding adolescent contributions to these conditions is one of GHDB’s high priority areas (see all GHDB high priority areas here); we hope these FOAs can help stimulate this important avenue of research.

  • Characterization of the Adolescent Reproductive Transition (R01)

  • Characterization of the Adolescent Reproductive Transition (R21)

  • Characterization of the Adolescent Reproductive Transition (R03)


Application Due Date(s): Standard dates apply, by 5:00 PM local time of applicant organization.

Purpose: The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research in the area of puberty and the trajectory of sexual development. Research using new technologies and approaches is needed to fill knowledge gaps and advance understanding of normative sexual development in both males and females. It is anticipated that the findings of studies supported by this FOA will advance knowledge of puberty and the establishment of reproductive competence.

Interested investigators can contact the scientific contact for the FOAs, Dr. Esther Eisenberg (, Telephone: 301-496-6516) or Dr. Candace Tingen of GHDB ( with any questions.


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